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Tag: narrow therapeutic index

Jan 3, 2026
Bridging Studies for NTI Generics: How Safety and Efficacy Are Ensured
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Bridging Studies for NTI Generics: How Safety and Efficacy Are Ensured

Bridging studies for NTI generics ensure that low-dose, high-risk medications like warfarin and levothyroxine are as safe and effective as brand versions. Stricter bioequivalence rules, complex study designs, and higher costs make these generics rare-but vital.

Dec 27, 2025
Why Some People React Differently to Generic Medications
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Why Some People React Differently to Generic Medications

Why do some patients feel worse after switching to generic medications? The answer lies in inactive ingredients and bioequivalence gaps-especially for drugs with narrow therapeutic indices like levothyroxine and warfarin.

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